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 MJ Fights Cancer & Helps Manage Side Effects Researcher Find 
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Modmin Dude
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Post MJ Fights Cancer & Helps Manage Side Effects Researcher Find
Daily Beast wrote:
Marijuana Fights Cancer and Helps Manage Side Effects, Researchers Find
Sep 6, 2012 4:45 AM EDT

Mounting evidence shows ‘cannabinoids’ in marijuana slow cancer growth, inhibit formation of new blood cells that feed a tumor, and help manage pain, fatigue, nausea, and other side effects.

Cristina Sanchez, a young biologist at Complutense University in Madrid, was studying cell metabolism when she noticed something peculiar. She had been screening brain cancer cells because they grow faster than normal cell lines and thus are useful for research purposes. But the cancer cells died each time they were exposed to tetrahydrocannabinol (THC), the principal psychoactive ingredient of marijuana.

Instead of gaining insight into how cells function, Sanchez had stumbled upon the anti-cancer properties of THC. In 1998, she reported in a European biochemistry journal that THC “induces apoptosis [cell death] in C6 glioma cells,” an aggressive form of brain cancer.

Subsequent peer-reviewed studies in several countries would show that THC and other marijuana-derived compounds, known as “cannabinoids,” are effective not only for cancer-symptom management (nausea, pain, loss of appetite, fatigue), they also confer a direct antitumoral effect.

A team of Spanish scientists led by Manuel Guzman conducted the first clinical trial assessing the antitumoral action of THC on human beings. Guzman administered pure THC via a catheter into the tumors of nine hospitalized patients with glioblastoma, who had failed to respond to standard brain-cancer therapies. The results were published in 2006 in the British Journal of Pharmacology: THC treatment was associated with significantly reduced tumor cell proliferation in every test subject.

Around the same time, Harvard University scientists reported that THC slows tumor growth in common lung cancer and “significantly reduces the ability of the cancer to spread.” What’s more, like a heat-seeking missile, THC selectively targets and destroys tumor cells while leaving healthy cells unscathed. Conventional chemotherapy drugs, by contrast, are highly toxic; they indiscriminately damage the brain and body.

There is mounting evidence, according to a report in Mini-Reviews in Medicinal Chemistry, that cannabinoids “represent a new class of anticancer drugs that retard cancer growth, inhibit angiogenesis [the formation of new blood cells that feed a tumor] and the metastatic spreading of cancer cells.”

Dr. Sean McAllister, a scientist at the Pacific Medical Center in San Francisco, has been studying cannabinoid compounds for 10 years in a quest to develop new therapeutic interventions for various cancers. Backed by grants from the National Institute of Health (and with a license from the DEA), McAllister discovered that cannabidiol (CBD), a nonpsychoactive component of the marijuana plant, is a potent inhibitor of breast cancer cell proliferation, metastasis, and tumor growth.

In 2007, McAllister published a detailed account of how cannabidiol kills breast cancer cells and destroys malignant tumors by switching off expression of the ID-1 gene, a protein that appears to play a major role as a cancer cell conductor.

The ID-1 gene is active during human embryonic development, after which it turns off and stays off. But in breast cancer and several other types of metastatic cancer, the ID-1 gene becomes active again, causing malignant cells to invade and metastasize. “Dozens of aggressive cancers express this gene,” explains McAllister. He postulates that CBD, by virtue of its ability to silence ID-1 expression, could be a breakthrough anti-cancer medication.

“Cannabidiol offers hope of a non-toxic therapy that could treat aggressive forms of cancer without any of the painful side effects of chemotherapy,” says McAllister, who is seeking support to conduct clinical trials with the marijuana compound on breast cancer patients.
McAllister’s lab also is analyzing how CBD works in combination with first-line chemotherapy agents. His research shows that cannabidiol, a potent antitumoral compound in its own right, acts synergistically with various anti-cancer pharmaceuticals, enhancing their impact while cutting the toxic dosage necessary for maximum effect.

Investigators at St. George’s University in London observed a similar pattern with THC, which magnified the effectiveness of conventional antileukemia therapies in preclinical studies. THC and cannabidiol both induce apoptosis in leukemic cell lines.

At the annual summer conference of the International Cannabinoid Research Society, held this year in Freiburg, Germany, 300 scientists from around the world discussed their latest findings, which are pointing the way toward novel treatment strategies for cancer and other degenerative diseases. Italian investigators described CBD as “the most efficacious inducer of apoptosis” in prostate cancer. Ditto for cannabidiol and colon cancer, according to British researchers at Lancaster University.

Within the medical science community, the discovery that cannabinoids have anti-tumoral properties is increasingly recognized as a seminal advancement in cancer therapeutics.

http://www.thedailybeast.com/articles/2 ... -find.html
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December 3rd, 2012, 3:51 pm
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Post Re: MJ Fights Cancer & Helps Manage Side Effects Researcher
There have also been numerous studies that have shown that smoking marijuana can CAUSE cancer.

Something that cannot be denied - pot smoke is carcinogenic, and carcinogens have been known to cause cancer. On top of that there is "tar," a common trait in cigarettes thought to cause cancer in joints or "marijuana cigarettes" as well.

I don't mind people claiming it "treats" cancer as an appetite enhancer or pain reducer, but I think it's a farce to say that it "fights" cancer. Even if it does allegedly help fight certain kinds, it seems to help to cause others.


December 3rd, 2012, 3:55 pm
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Post Re: MJ Fights Cancer & Helps Manage Side Effects Researcher
wjb21ndtown wrote:
There have also been numerous studies that have shown that smoking marijuana can CAUSE cancer.
And like these studies that say they help, they have to be taken with a grain of salt. They are only studies, not trials after all.
wjb21ndtown wrote:
Something that cannot be denied - pot smoke is carcinogenic, and carcinogens have been known to cause cancer. On top of that there is "tar," a common trait in cigarettes thought to cause cancer in joints or "marijuana cigarettes" as well.
Agree on the carcinogens, they're in all smoke. That said, who says you have to smoke cannabis
wjb21ndtown wrote:
I don't mind people claiming it "treats" cancer as an appetite enhancer or pain reducer, but I think it's a farce to say that it "fights" cancer. Even if it does allegedly help fight certain kinds, it seems to help to cause others.
Considering as many of the pharmaceutics being prescribed for one ailment causes other ailments, why is it so hard to believe that cannabis could possibly help fight some yet perhaps be related to causing others? Is that so hard to believe? Really? When was the last time you saw an ad / commercial for medication that didn't list side effects??? Has there ever been one?

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December 3rd, 2012, 4:14 pm
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Post Re: MJ Fights Cancer & Helps Manage Side Effects Researcher
TheRealWags wrote:
Considering as many of the pharmaceutics being prescribed for one ailment causes other ailments, why is it so hard to believe that cannabis could possibly help fight some yet perhaps be related to causing others? Is that so hard to believe? Really? When was the last time you saw an ad / commercial for medication that didn't list side effects??? Has there ever been one?


The vast majority of cannibus is smoked, you know that. I'd be willing to bet that 90% or more of it is ingested via smoking the substance, and if it's not "smoking" it that they prefer, or if it is ingested some other way for these "studies" I think they should make that well known, as most of the public that does in fact use it, smokes it.

My issue is that they're claiming that it fights "cancer" as a blanket statement, when it has been known (or at least believed) to cause some types of cancer. If they want to specify that it "fights" or "treats" prostate cancer, breast cancer, etc., I'm all for that, as long as studies conclude it. What I have a problem with is the blanket statement "it fights cancer." That statement is misleading, and implies that it does not cause any types of cancer.

Sure, some drugs have side effects, but the side effect is never the disease itself. You never see cholesterol drug A with a side effect of "may raise cholesterol," or anti-biotic B with a side effect of "may encourage bacteria growth." Here the "side effect" that your claiming IS in fact the disease that it allegedly treats.


December 3rd, 2012, 4:54 pm
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Post Re: MJ Fights Cancer & Helps Manage Side Effects Researcher
Most of mj today is taken as an inhalant. Of that there can be no dispute. But wags has a very valid point saying that it does not have to be. Before card carrying here n Michigan, Magic cookies were a rarity. Darn near a myth, but now that it has basically become legalized i have personally seen treats I never even imagined would be made" magical". Because of the legality there has been a growing abundance of options on how to intake thc. It seems silly to think that as pot becomes more and more legalized that the trend won't continue. I'm kind of surprised that pill form is not a common prescription yet.. ( it would make it easier to tax)

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December 3rd, 2012, 8:33 pm
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